Search results for "Point mutations"

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Innovative and Applied Research in Biology: Proceedings

2022

The collection contains SCIENTIFIC articles on the topics of the LU 80 conference reports. The main focus is on innovative and applied research in biology and interdisciplinary fields.

DiatomsRed beetroot juiceLow frequency electromagnetic radiationEU habitatsRare and threatened speciesArtificial lightCloudberry:NATURAL SCIENCES::Biology [Research Subject Categories]Pest controlYellow sticky trapsSpecially protected whorl snails (Vertigo spp.)Aquatic pollutionPoint mutationsBioindicatorsGlutathione peroxidaseGreenhouse whitefliesDuckweed Lemna minorThe Daugava RiverPro/antioxidative actionChlorophyll fluorescenceNature protectionSpecific Pollution Sensitivity Index (IPS)
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Differential effects of oncogenic H- and K-ras expression on HT-29 colorectal carcinoma cell line.

2008

The Ras oncogene is mutated in about 30% of the human tumors and its mutations are always point mutations concerning codon 12, 13 and 61. These mutations cause in the proteins a reduced GTPase activity, so that they become constitutively active. In human cells there are three main isoforms of Ras (H, K, N-ras) which can trigger alternative pathways of signal trasduction. In order to investigate the effects of expression of different oncogenic Ras isoforms in colorectal carcinoma cells (HT-29), we obtained stable clones of HT-29 cells transfected with cDNAs codifying H-RasG12V and K-Ras G12V called respectively H12 and K12 and K-RasG13D called K13, under the control of an hormone-inducible p…

ras oncogenetmorpoint mutations.
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